A novel network approach reveals tissue-specific cellular modulators of the immune-fibrotic axis in systemic sclerosis
نویسندگان
چکیده
11 Affiliations: 12 1 Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH 03755 USA 13 2 Department of Neurological Sciences, University of Vermont, Burlington, VT 05405 USA 14 3 Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of 15 Pennsylvania, Philadelphia, PA 19104 USA 16 4 Division of Rheumatology 5 Pulmonary Center, Department of Medicine, Boston University School of Medicine, 17 Boston, MA, 02118, USA 18 6 Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh Medical 19 Center, Pittsburgh. PA, 15261 USA 20 Division of Medicine, University College London, London, UK 21 8 Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 22 Chicago, IL, 60611, USA 23 9 Department of Obstetrics and Gynecology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756 USA 24 25 26
منابع مشابه
A novel multi - network approach reveals tissue - specific 1 cellular modulators of fibrosis in systemic sclerosis , 2 pulmonary fibrosis and pulmonary arterial hypertension 3 4
A novel multi-network approach reveals tissue-specific 1 cellular modulators of fibrosis in systemic sclerosis, 2 pulmonary fibrosis and pulmonary arterial hypertension 3 4 Jaclyn N. Taroni, Casey S. Greene, Viktor Martyanov, Tammara A. Wood, Romy B. 5 Christmann, Harrison W. Farber, Robert A. Lafyatis, Christopher P. Denton, Monique E. 6 Hinchcliff, Patricia A. Pioli, J. Matthew Mahoney§, Mich...
متن کاملThe Growth Arrest-Specific Transcript 5 (GAS5) and Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1): Novel Markers Involved in Multiple Sclerosis
Recent studies have revealed that long non-coding RNAs (lncRNAs) are connected with pathogenesis of neurodegenerative diseases. Additionally, glucocorticoids have fundamental regulatory roles on the immune system, and act as potent therapeutic compounds for autoimmune and inflammatory diseases. The long noncoding RNA growth arrest-specific 5 (GAS5) which accumulates inside the cells in response...
متن کاملPhysiology in Medicine: a Series of Articles Linking Medicine with Science
Abnormal and exaggerated deposition of extracellular matrix is the hallmark of many fibrotic diseases, including systemic sclerosis and pulmonary, liver, and kidney fibrosis. The spectrum of affected organs, the usually progressive nature of the fibrotic process, the large number of affected persons, and the absence of effective treatment pose an enormous challenge when treating fibrotic diseas...
متن کاملA Novel Approach for Detecting Relationships in Social Networks Using Cellular Automata Based Graph Coloring
All the social networks can be modeled as a graph, where each roles as vertex and each relationroles as an edge. The graph can be show as G = [V;E], where V is the set of vertices and E is theset of edges. All social networks can be segmented to K groups, where there are members in eachgroup with same features. In each group each person knows other individuals and is in touch ...
متن کاملComparison of a Suggested Model of Fibrosis in Human Dermal Fibroblasts by Serum from Systemic Sclerosis Patients with Transforming Growth Factor β Induced in vitro Model
Systemic sclerosis (SSc) is a chronic autoimmune disease, featuring fibrosis in multiple organs. The serum from SSc patients contain inflammatory mediators, contributing to SSc pathogenesis and could be used to develop cell culture models. Here, we compared the fibrotic effects of serum samples from SSc patients with TGFβ1 on human dermal fibroblasts (HDFs). HDF cells were cultured in four diff...
متن کامل